Hypodysfibrinogenemia
Fibrinogen is one of the clotting factor proteins that are needed to help the body form a blood clot to stop bleeding. People diagnosed with Hypodysfibrinogenemia do not have enough fibrinogen in the blood and the fibrinogen they do have does not work correctly. This can delay the time it takes to make a blood clot and for this blood clot to be weak causing bleeding to last longer or to stop and then start back up again. Though Hypodysfibrinogenemia is considered a bleeding disorder, there is also a risk for increased clotting because the poorly working fibrinogen can also cause problems with the normal breakdown of a blood clot the body has made. Increased clotting can cause a thrombosis (a blood clot that prevents blood flow) to form.
Hypodysfibrinogenemia is a very rare inherited bleeding disorder. One or both parents can pass the abnormal gene to their child. If one parent passes the gene to their child, it is called heterozygous and usually symptoms are minimal. If both parents pass the affected gene to their child, it is called homozygous and makes the risk for much bleeding higher because both genes are affected.